Cell volume regulation and swelling-activated chloride channels
نویسندگان
چکیده
منابع مشابه
Swelling-activated chloride channels in multidrug-sensitive and - resistant cells
Resistance to chemotherapeutic agents in neoplastic cells is often mediated by expression of P-glycoprotein, which functions as a drug-efflux pump for a broad range of substrates. We have used a combination of patch clamp and video-imaging techniques to examine the expression and drug-efflux function of P-glycoprotein and to determine the possible correlation with swelling-activated chloride ch...
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Cell volume regulation is one of the most fundamental homeostatic mechanisms and essential for normal cellular function. At the same time, however, many physiological mechanisms are associated with regulatory changes in cell size meaning that the set point for cell volume regulation is under physiological control. Thus, cell volume is under a tight and dynamic control and abnormal cell volume r...
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Swelling-Activated Chloride Channels? To the Editor: We want to make the readers of Circulation Research aware of challenges that have arisen regarding an article that was recently published by Diaz et al1 in Circulation Research. They proposed the attractive idea that improved cellular volume control through opening of swelling-activated chloride channels was responsible for the infarct size r...
متن کاملSwelling-activated chloride channels in leech Retzius neurons.
During periods of high activity neurons are expected to swell due to the uptake of Cl(-). To find out whether leech Retzius neurons possess swelling-activated Cl(-) channels that facilitate Cl(-) efflux and, hence, volume recovery, we exposed the cells to hypotonic solutions. In hypotonic solutions, the cells slowly swelled but did not undergo a regulatory volume decrease. However, the cell vol...
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Channel-mediated trans-membrane chloride movement is a key process in the active cell volume regulation under osmotic stress in most cells. However, thymocytes were hypothesized to regulate their volume by activating a coupled K-Cl cotransport mechanism. Under the patch-clamp, we found that osmotic swelling activates two types of macroscopic anion conductance with different voltage-dependence a...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2003
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2003.10.008